Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
 |
|
|
||||||||||||||||||||||||||||||||||||||||||
| Title: | Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide |
| Inventors: | Tang, Y. Tom; San Jose, CA, USA Labat, Ivan; Mountain View, CA, USA Drmanac, Radoje T.; Palo Alto, CA, USA Mize, Nancy; Mountain View, CA, USA Nishikawa, Mitsuo; Gunma, Japan Chao, Cheng-Chi; Cupertino, CA, USA |
| Summary: | Described herein is an ex vivo method of promoting the proliferation of a hematopoietic stem cell, via contacting the cell with a polypeptide. The invention relates to novel polynucleotides and polypeptides encoded by such polynucleotides, and mutants or variants thereof, which correspond to a novel human stem cell growth factor-like protein. Further described are polynucleotides comprising nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Further disclosed are vectors containing processes for the production of such novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. Thereapeutic applications are included, such as in the promotion of wound healing, and as a medicine to proliferate or support human hematopoietic stem cells or human hematopoietic progenitor cells. |
| Abstract: | The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6824973 |
| Application Number: | US2001000894912 |
| Date Filed: | 28/06/2001 |
| Date Published: | 30/11/2004 |
| Assignee: | Kirin Beer Kabushiki Kaisha, Tokyo, Japan |