Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6825326

Title:PSCA: prostate stem cell antigen and uses thereof
Inventors:Reiter, Robert E.; Los Angeles, CA, USA
Witte, Owen N.; Sherman Oaks, CA, USA
Summary:Described herein is a novel prostate stem cell antigen protein, PSCA, which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. The invention relates to a monoclonal antibody which specifically binds to the epitope bound by the monoclonal antibody produced by any one of the hybridomas designated HB-12612, HB-12613, HB-12614, HB-12616, HB-12618, HB-12615, or HB-12617, as deposited with the American Type Culture Collection. Therapeutic applications are provided, such as in the diagnosis and treatment of prostate cancer, in the production of vaccines and in the generation of antibodies for use in assays.
Abstract:The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6825326
Application Number:US2001000934773
Date Filed:21/08/2001
Date Published:30/11/2004
Assignee:The Regents of the University of California, Oakland, CA, USA


 
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