Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6830927

Title:Common neural progenitor for the CNS and PNS
Inventors:Rao, Mahendra S.; Salt Lake City, UT, USA
Mujtaba, Tahmina; Sandy, UT, USA
Summary:Described herein is a method of generating mammalian neuroepithelial stem cells and glial restricted precursor cells which are self-renewing and can differentiate into central nervous system cells. The invention relates to a method of generating neural crest stem cells via inducing the neuroepithelial stem cells to differentiate in vitro into neural crest stem cells by replating the cells on laminin, withdrawing mitogens, or adding dorsalizing agents to the growth medium. Further disclosed are methods by which derivatives of the peripheral nervous system can be generated by inducing the neural crest stem cells to differentiate in vitro.
Abstract:A method of generating neural crest stem cells involves inducing neuroepithelial stem cells to differentiate in vitro into neural crest stem cells. Differentiation can be induced by replating the cells on laminin, withdrawing mitogens, or adding dorsalizing agents to the growth medium. Derivatives of the peripheral nervous system can be generated by inducing the neural crest stem cells to differentiate in vitro.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6830927
Application Number:US1998000073881
Date Filed:06/05/1998
Date Published:14/12/2004
Assignee:University of Utah Research Foundation, Salt Lake City, UT, USA


 
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