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Stem Cell Related Patent Number US6833269
| Title: | Making neural cells for human therapy or drug screening from human embryonic stem cells | | Inventors: | Carpenter, Melissa K.; Castro Valley, CA, USA | | Summary: | Described herein is a novel neural progenitor cell population which proliferates in vitro and is obtained by differentiating primate pluripotent stem cells. The invention relates to populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes which are obtained by culturing the stem cell populations in a cocktail of growth conditions that initiates differentiation and establishes the neural progenitor population. Further described are methods by which the progenitors can be differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. Therapeutic applications are included, such as in the reconstitution or supplementation of central nervous system function, and in the generation of large quantities of neural cells for drug screening and in the treatment of neurological disorders. | | Abstract: | This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6833269 | | Application Number: | US2001000872183 | | Date Filed: | 31/05/2001 | | Date Published: | 21/12/2004 | | Assignee: | Geron Corporation, Menlo Park, CA, USA |
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