Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6846676

Title:In Vivo production and delivery of erythropoietin or insulinotropin for gene therapy
Inventors:Selden, Richard F.; Wellesley, MA, USA
Treco, Douglas; Arlington, MA, USA
Heartlein, Michael W.; Boxborough, MA, USA
Summary:This invention describes primary and secondary cells that are transfected with a nucleic acid molecule for encoding erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains. The in vivo transfection of the cell is discussed, along with the exogenous DNA that encodes erythropoietin, and the DNA sequences that direct expression of the exogenous DNA in the primary or secondary cell.
Abstract:The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains. The present invention includes primary and secondary somatic cells, such as fibroblasts, keratinocytes, epithelial cells, endothelial cells, glial cells, neural cells, formed elements of the blood, muscle cells, other somatic cells which can be cultured and somatic cell precursors, which have been transfected with exogenous DNA encoding EPO or an insulinotropin, which is stably integrated into their genomes or is expressed in the cells episomally.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6846676
Application Number:US1999000328130
Date Filed:08/06/1999
Date Published:25/01/2005
Assignee:Transkaryotic Therapies, Inc., Cambridge, MA, USA


 
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