Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6858583

Title:Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
Inventors:Tsyrlova, Irena; Gaithersburg, MD, USA
Wolpe, Stephen D.; Rockville, MD, USA
Summary:Described herein are inhibitors of stem cell proliferation comprised of hemoglobin chains, and methods for the isolation and uses thereof. The invention relates to alpha chain peptide fragments, and the means by which such fragments are employed in the regulation of abnormal stem cell cycles, and in the acceleration of post-chemotherapy peripheral blood cell recovery. Therapeutic applications are disclosed, such as in the protection of stem cells from antiviral agents, in the treatment of cancer, and in the maintenance of mammalian hematopoietic stem cells ex vivo.
Abstract:Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6858583
Application Number:US2003000463699
Date Filed:18/06/2003
Date Published:22/02/2005
Assignee:Wellstat Therapeutics Corporation, Gaithersburg, MD, USA


 
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