Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6863900

Title:Regeneration and augmentation of bone using mesenchymal stem cells
Inventors:Kadiyala, Sudhakar; Baltimore, MD, USA
Bruder, Scott P.; Owings Mills, MD, USA
Summary:Described herein are methods of regeneration and augmentation of bone via the use of isolated human mesenchymal stem cells (hMSCs) and a medium which supports their differentiation into osteogenic cells. The invention relates to methods and compositions for augmenting bone formation by administering isolated hMSCs with a ceramic material or matrix, or via the administration of fresh, whole marrow, or via combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Therapeutic applications are included, such as in the treatment of muscle- and bone-related injury or dysfunction.
Abstract:Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6863900
Application Number:US2002000840284
Date Filed:26/06/2002
Date Published:08/03/2005
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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