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Stem Cell Related Patent Number US6875430
| Title: | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation | | Inventors: | McIntosh, Kevin R.; Ellicott City, MD, USA
Mosca, Joseph D.; Ellicott City, MD, USA
Klyushnenkova, Elena; Baltimore, MD, USA | | Summary: | Described herein are mesenchymal stem cells and their use in the prevention, reduction or treatment of transplant rejection or of graft-versus-host disease. The invention relates to a method of reducing an immune response to a transplant in a recipient by treatment of the recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. Further described are means of administering the mesenchymal stem cells prior to, concomitant with, or following the transplant, such that the recipient receives effector cells that have a reduced immune response against a xenoantigen. Therapeutic applications in graft-versus-host disease are included. | | Abstract: | A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6875430 | | Application Number: | US2001000067121 | | Date Filed: | 13/11/2001 | | Date Published: | 05/04/2005 | | Assignee: | Osiris Therapeutics, Inc., Baltimore, MD, USA |
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