Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6875430

Title:Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Inventors:McIntosh, Kevin R.; Ellicott City, MD, USA
Mosca, Joseph D.; Ellicott City, MD, USA
Klyushnenkova, Elena; Baltimore, MD, USA
Summary:Described herein are mesenchymal stem cells and their use in the prevention, reduction or treatment of transplant rejection or of graft-versus-host disease. The invention relates to a method of reducing an immune response to a transplant in a recipient by treatment of the recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. Further described are means of administering the mesenchymal stem cells prior to, concomitant with, or following the transplant, such that the recipient receives effector cells that have a reduced immune response against a xenoantigen. Therapeutic applications in graft-versus-host disease are included.
Abstract:A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6875430
Application Number:US2001000067121
Date Filed:13/11/2001
Date Published:05/04/2005
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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