Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6875608

Title:Propagation and/or derivation of embryonic stem cells
Inventors:Smith, Austin Gerard; Edinburgh, United Kingdom
Burdon, Thomas Grant; Edinburgh, United Kingdom
Summary:Described herein are methods of culturing embryonic stem (ES) cells without differentiation, and uses thereof. The invention relates to ES cells that are cultured in the presence of a compound which selectively inhibits the propagation or survival of cells other than ES cells. The ES cells are described as not having been genetically altered, but rather, the compound employed herein inhibits a signaling pathway which is essential for the propagation of differentiated cells but not for the propagation of ES cells. The resulting ES cells are selectively maintainable in the culture, and are useful for studying the regulation of stem cell self-renewal, in media that are selective against differentiated cell types.
Abstract:Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not essential for propagation of ES cells—hence ES cells are selectively maintained in the culture
US Patent Website:Click Here for Full Text of Patent
Title Number:US6875608
Application Number:US1999000786817
Date Filed:13/09/1999
Date Published:05/04/2005
Assignee:University of Edinburgh, Edinburgh, United Kingdom


 
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