Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6878542

Title:Isolation, selection and propagation of animal transgenic stem cells
Inventors:Smith, Austin Gerard; Edinburgh, United Kingdom
Mountford, Peter Scott; Elsdenwid, Australia
Summary:This invention describes in vitro methods of isolation, enrichment and/or the selective propagation of animal stem cells. Disclosed herein are the means by which cells are transfected with a selectable marker, such as an antibiotic resistance gene, the differential expression of which allows for the selection and/or maintenance of cells. Methods are provided by which animal stem cells are obtained and maintained by the culturing of cells containing a selectable marker in the genome, as well as a differential expression of the selectable marker which enables preferential survival and/or division of the desired stem cells when compared to non-stem cells.
Abstract:Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker; differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to non-stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6878542
Application Number:US2000000537562
Date Filed:30/03/2000
Date Published:12/04/2005
Assignee:The University of Edinburgh United Kingdom


 
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