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Stem Cell Related Patent Number US6878542
| Title: | Isolation, selection and propagation of animal transgenic stem cells | | Inventors: | Smith, Austin Gerard; Edinburgh, United Kingdom
Mountford, Peter Scott; Elsdenwid, Australia | | Summary: | This invention describes in vitro methods of isolation, enrichment and/or the selective propagation of animal stem cells. Disclosed herein are the means by which cells are transfected with a selectable marker, such as an antibiotic resistance gene, the differential expression of which allows for the selection and/or maintenance of cells. Methods are provided by which animal stem cells are obtained and maintained by the culturing of cells containing a selectable marker in the genome, as well as a differential expression of the selectable marker which enables preferential survival and/or division of the desired stem cells when compared to non-stem cells. | | Abstract: | Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker; differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to non-stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6878542 | | Application Number: | US2000000537562 | | Date Filed: | 30/03/2000 | | Date Published: | 12/04/2005 | | Assignee: | The University of Edinburgh United Kingdom |
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