Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6900017

Title:Human hematopoietic growth regulatory gene and uses
Inventors:Sharma, Arun; Oak Park, IL, USA
Hoffman, Ronald; Chicago, IL, USA
Summary:Described herein are novel hiwi nucleic acid proteins and genes encoding such proteins. The invention is related to the isolation of complementary DNA copies of mRNA of a human hiwi gene, including also the recombinant expression constructs which are capable of expressing the human hiwi gene in cultures of transformed prokaryotic and eukaryotic cells. Further provided are cultures of transformed cells that synthesize the human hiwi proteins encoded therein. Therapeutic applications are included, such as for screening compounds which modulate hiwi in the treatment of cancer.
Abstract:The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding a human hiwi gene. Also provided are recombinant expression constructs capable of expressing the human hiwi gene of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human hiwi proteins encoded therein. The invention also provides methods for isolating human hematopoietic stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6900017
Application Number:US2002000043774
Date Filed:10/01/2002
Date Published:31/05/2005
Assignee:The Board of Trustees of the University of Illinois, Urbana, IL, USA


 
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