Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6900054

Title:Lineage restricted glial precursors from the central nervous system
Inventors:Rao, Mahendra S.; Salt Lake City, UT, USA
Summary:Described herein is a population of mammalian central nervous system glial restricted precusor (GRP) cells, and uses thereof. The invention relates to A2B5+ E-NCAM- GRP cells which are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5- fibroblast-like astrocytes, but not into neurons. Further provided are methods by which such GRP cells can be maintained by regeneration in culture. The GRP cells are described as differing from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Applications and therapeutic uses are included.
Abstract:A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5 fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6900054
Application Number:US2000000736728
Date Filed:14/12/2000
Date Published:31/05/2005
Assignee:University of Utah Research Foundation, Salt Lake City, UT, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021