Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6905678

Title:Gene delivery vectors with cell type specificity for mesenchymal stem cells
Inventors:Havenga, Menzo Jans Emco; Alphen a/d Rijn, Netherlands Bout, Abraham; Moerkapelle, Netherlands Vogels, Ronald; Linschoten, Netherlands
Summary:Described herein is the use of a recombinant adenoviral vector for the transduction of a heterologous nucleic acid to a mesenchymal stem cell. Mesenchymal stem cells are described as being a recently discovered type of stem cell for which suitable transfer vehicles are still desired, since gene delivery vehicles such as the adenoviruses or adeno-associated viruses typically have no particular tropism for mesenchymal stem cells. Disclosed herein is a novel form of transduction specifically for mesenchymal stem cells, as well as therapeutic applications thereof, such as in gene therapy for the treatment of rheumatoid arthritis, multiple sclerosis or bone-related disorders.
Abstract:Methods and associated materials for transducing mesenchymal stem cells with a desired nucleic acid. Mesenchymal stem cells are a recently discovered kind of stem cell for which suitable transfer vehicles are still desired. Typical gene delivery vehicles such as the adenoviruses or adeno associated viruses have no particular tropism for mesenchymal stem cells. Also disclosed is gene therapy using adenoviruses provided with tropism for mesenchymal stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6905678
Application Number:US2001000010645
Date Filed:13/11/2001
Date Published:14/06/2005
Assignee:Crucell Holland B.V., Leiden, Netherlands


 
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