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Stem Cell Related Patent Number US6905678
| Title: | Gene delivery vectors with cell type specificity for mesenchymal stem cells | | Inventors: | Havenga, Menzo Jans Emco; Alphen a/d Rijn, Netherlands
Bout, Abraham; Moerkapelle, Netherlands
Vogels, Ronald; Linschoten, Netherlands | | Summary: | Described herein is the use of a recombinant adenoviral vector for the transduction of a heterologous nucleic acid to a mesenchymal stem cell. Mesenchymal stem cells are described as being a recently discovered type of stem cell for which suitable transfer vehicles are still desired, since gene delivery vehicles such as the adenoviruses or adeno-associated viruses typically have no particular tropism for mesenchymal stem cells. Disclosed herein is a novel form of transduction specifically for mesenchymal stem cells, as well as therapeutic applications thereof, such as in gene therapy for the treatment of rheumatoid arthritis, multiple sclerosis or bone-related disorders. | | Abstract: | Methods and associated materials for transducing mesenchymal stem cells with a desired nucleic acid. Mesenchymal stem cells are a recently discovered kind of stem cell for which suitable transfer vehicles are still desired. Typical gene delivery vehicles such as the adenoviruses or adeno associated viruses have no particular tropism for mesenchymal stem cells. Also disclosed is gene therapy using adenoviruses provided with tropism for mesenchymal stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6905678 | | Application Number: | US2001000010645 | | Date Filed: | 13/11/2001 | | Date Published: | 14/06/2005 | | Assignee: | Crucell Holland B.V., Leiden, Netherlands |
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