Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6919206

Title:Medium containing flt3 ligand for culturing hematophoietic cells
Inventors:Lyman, Stewart D.; Seattle, WA, USA
Beckmann, M. Patricia; Poulsbo, WA, USA
Summary:This invention describes isolated ligands for flt 3 receptors capable of transducing self-renewal signals in the regulation of growth, proliferation or differentiation of progenitor cells and stem cells. Further disclosed are flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Therapeutic applications are included, such as in the treatment of anaemia, AIDS and cancer.
Abstract:Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6919206
Application Number:US1997000994468
Date Filed:19/12/1997
Date Published:19/07/2005
Assignee:Immunex Corporation, Thousand Oaks, CA, USA


 
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