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Stem Cell Related Patent Number US6919432
| Title: | Substances and their uses | | Inventors: | Wells, Timothy N. C.; Geneva, Switzerland
Power, Christine A.; Geneva, Switzerland | | Summary: | This invention describes a chemokine receptor which binds to MIP-1-alpha, RANTES and/or MCP-1. Further disclosed is an isolated antibody binding to a chemokine receptor polypeptide CC-CKR-4 comprised of a specific amino acid sequence, in which the antibody binds to an epitope identified with that sequence. Applications are provided in the screening of agents which act as antagonists to MCP-1, MIP-1-alpha and/or RANTES, as such agents may be useful in the treatment of various disorders, including allergies, atheromas, asthma, eczema, atopic dermatitis, rhinitis, conjunctivitis, and diseases mediated by viruses. Also included are applications in the prevention of graft rejection and in the protection of stem cells from the potentially damaging effects of chemotherapy. | | Abstract: | A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated by viruses. They may also be useful in preventing graft rejection and in protecting stem cells from potentially damaging effects of chemotherapy. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6919432 | | Application Number: | US2001000764413 | | Date Filed: | 19/01/2001 | | Date Published: | 19/07/2005 | | Assignee: | Glaxo Group Limited, Greenford Middlesex, United Kingdom |
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