|
|
|
Stem Cell Related Patent Number US6924096
| Title: | Delivery construct for antisense nucleic acids and methods of use | | Inventors: | Dietz, Harry C.; Towson, MD, USA | | Summary: | This invention describes a novel nucleic acid construct for the delivery of antisense targeting sequences, such that the construct includes intact stem loop structures and an antisense nucleic acid itself. Further disclosed are optional methods by which a ribozyme nucleic acid is included in the construct. Therapeutic applications are provided, such as in the suppression and inhibition of selected genes in a cell and in allele-specific targeting in combination with replacement gene therapy. | | Abstract: | A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6924096 | | Application Number: | US1998000163289 | | Date Filed: | 29/09/1998 | | Date Published: | 02/08/2005 | | Assignee: | The Johns Hopkins University School of Medicine, Baltimore, MD, USA |
|
|
