Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6933150

Title:Relationship of ABC transport proteins with hematopoietic stem cells and methods of use thereof
Inventors:Sorrentino, Brian; Memphis, TN, USA
Bunting, Kevin; Columbus, MD, USA
Schuetz, John; Memphis, TN, USA
Nakauchi, Hiromitsu; Kukizaki-machi, Japan
Summary:Described herein are methods of identifying a stem cell via detecting the expression of an ATP transport protein (BCRP) by a cell. The invention relates to methods of performing ex vivo expansion of gene-modified hematopoietic stem cells which can also contain a second heterologous gene. Further disclosed are methods of engrafting the gene-modified hematopoietic stem cells into animals, including for ex vivo gene therapy and for reconstitution of hematopoietic cells in ablated mammals. Therapeutic applications are included, such as in the treatment of muscular dystrophy, myocardial infarction, Parkinson's disease, neurodegenerative disorders, and in bone marrow transplantation.
Abstract:The present invention includes methods of performing ex vivo expansion of gene-modified hematopoietic stem cells which are useful for many applications involving bone marrow transplantation and ex vivo gene therapy. The present invention further includes the gene-modified hematopoietic stem cells that are used and produced by such methods. Such gene-modified hematopoietic stem cells can also contain a second heterologous gene. In addition, the present invention also includes methods of engrafting the gene-modified hematopoietic stem cells of the present invention into animals, including for ex vivo gene therapy and for reconstitution of hematopoietic cells in ablated mammals. The present invention also provides a method of isolating stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6933150
Application Number:US2000000584586
Date Filed:31/05/2000
Date Published:23/08/2005
Assignee:St. Jude Children's Research Hospital, Memphis, TN, USA


 
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