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| Title: | Expansion of hematopoietic cells using midkine or pleiotrophin |
| Inventors: | Kikuchi, Makoto; Fukuoka, Japan Ikematsu, Shinya; Kanagawa, Japan Oda, Munehiro; Kanagawa, Japan Sakuma, Sadatoshi; Kanagawa, Japan Muramatsu, Takashi; Aichi, Japan |
| Summary: | Described herein is a method of expansion of the differentiation and growth of mammalian hematopoietic stem cells and/or prodromal haematopoietic cells, via the novel use of the MK family alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. Further disclosed is are methods of utilizing the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO. Therapeutic applications are provided, such as in the treatment of neutropenia and the ex vivo expansion of haematopoietic stem cells used in bone marrow transplants. |
| Abstract: | The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6939669 |
| Application Number: | US2002000071039 |
| Date Filed: | 08/02/2002 |
| Date Published: | 06/09/2005 |
| Assignee: | Meiji Dairies Corporation, Tokyo, Japan |