Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6939669

Title:Expansion of hematopoietic cells using midkine or pleiotrophin
Inventors:Kikuchi, Makoto; Fukuoka, Japan
Ikematsu, Shinya; Kanagawa, Japan
Oda, Munehiro; Kanagawa, Japan
Sakuma, Sadatoshi; Kanagawa, Japan
Muramatsu, Takashi; Aichi, Japan
Summary:Described herein is a method of expansion of the differentiation and growth of mammalian hematopoietic stem cells and/or prodromal haematopoietic cells, via the novel use of the MK family alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. Further disclosed is are methods of utilizing the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO. Therapeutic applications are provided, such as in the treatment of neutropenia and the ex vivo expansion of haematopoietic stem cells used in bone marrow transplants.
Abstract:The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6939669
Application Number:US2002000071039
Date Filed:08/02/2002
Date Published:06/09/2005
Assignee:Meiji Dairies Corporation, Tokyo, Japan


 
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