Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6939955

Title:Hematopoietic growth factor inducible neurokinin-1 gene
Inventors:Rameshwar, Pranela; Maplewood, NJ, USA
Summary:Described herein is a hematopoietic growth factor inducible neurokin-1 type polypeptide and polynucleotide, methods and uses thereof. This invention relates to the fact that bone marrow (BM) is the primary organ in which immune cells are derived, and homeostasis in the BM is maintained by inter- and intra-cellular interactions among the various subsets of BM cells. Disclose herein are methods of cloning a new cDNA from stimulated BM stromal cells retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. Since the cloned cDNA was designated the “Hematopoietic Growth Factor Inducible Neurokinin-1 type” (HGFIN) gene based on its expression in differentiated hematopoietic cells, a novel gene, HGFIN, is introduced herein, which encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. Also described are uses of the protein, for example, as a central mediator of white blood cells, progenitor cells, in the processes of differentiation and in the prevention and treatment of lymphoproliferative syndromes such as B-cell related maladies, including but not limited to acute and chronic myeloid and lymphocytic leukemia as well as the B-cell subtype of Hodgkin's and non-Hodgkin's lymphomas. Therapeutic applications are provided, especially in the treatment of diseases associated with abnormal bone marrow cell differentiation or proliferation, such as leukemia.
Abstract:Bone marrow (BM) is the major organ where immune cells are derived. Homeostasis in the BM is maintained by inter- and intra-cellular interactions by the various subsets of BM cells. The present invention discloses the cloning of a new cDNA from stimulated BM stromal cells that was retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. The cloned cDNA was designated ‘Hematopoietic Growth Factor Inducible Neurokinin-1 type’ (HGFIN) gene based on its expression in differentiated hematopoietic cells. Hence, the present invention provides a novel gene, HGFIN, which encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. The protein of the present invention may be involved as a central mediator of white blood cell, progenitor, differentiation, and therefore, may be useful in the prevention and treatment of lymphoproliferative syndromes such as B-cell related maladies, including but not limited to acute and chronic myeloid and lymphocytic leukemia as well as the B-cell subtype of Hodgkin's and non-Hodgkin's lymphomas.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6939955
Application Number:US2001000039272
Date Filed:20/10/2001
Date Published:06/09/2005
Assignee:University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA


 
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