Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6946266

Title:Gene transfer in chicken bursal stem cells
Inventors:Neiman, Paul E.; Seattle, WA, USA
Summary:Described herein are methods for the large scale production of a selected polypeptide in an avian host via the ablation of lymphoid cells in an avian embryo, followed by the infusion of transformed bursal stem cells into the embryo. The invention relates to a method of expressing proteins in higher eukaryotes in vitro via the expression of exogenous proteins as fusion partners with the immunoglobulin molecules of avian species, specifically, chickens. Described herein are methods of retroviral-mediated gene transfer and transplantation of stem cells from the Bursa of Fabricus in chickens.
Abstract:The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The technology involves, in one embodiment, retroviral-mediated gene transfer and transplantation of stem cells from the Bursa of Fabricus in chickens.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6946266
Application Number:US2001000025199
Date Filed:18/12/2001
Date Published:20/09/2005
Assignee:Fred Hutchinson Cancer Research Center, Seattle, WA, USA


 
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