Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6949623

Title:Method for gene transfer into target cells with retrovirus
Inventors:Asada, Kiyozo; Shiga, Japan
Summary:Described herein is a method for increasing the efficacy of gene transfer to a target cell using a retrovirus. The invention provides a method for increasing the efficiency of gene transfer into target cells such that the transduction is affected by infecting target cells with a retrovirus in the presence of a mixture of a functional material having a retrovirus binding domain, and a second functional material having a target cell binding domain. The target cells may be selected from the group of unintentional hematopoietic progenitor cells and erythrocyte precursors, specifically pluripotent stem cells or embryopalstic stem cells.
Abstract:The present invention provides a method for increasing the efficiency of gene transfer into target cells with a retrovirus. The transduction is affected by infecting target cells with a retrovirus in the presence of a mixture of a functional material having a retrovirus binding domain, and a second functional material having target cell binding domain. The target cells may be selected from the group of unintentional hematopoietic progenitor cells and erythrocyte precursor, specifically pluripotent stem cells or embryopalstic stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6949623
Application Number:US2001000775964
Date Filed:02/02/2001
Date Published:27/09/2005
Assignee:Takara Bio Inc. Japan


 
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