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Stem Cell Related Patent Number US6969608

Title:Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
Inventors:Miller, Freda; Montreal, Canada
Summary:This invention describes isolated precursor cells containing sensory receptors. Central to the invention is the discovery that current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. Described herein are methods by which neural precursor cells (stem cells, progenitor cells or a combination thereof) isolated from the olfactory epithelium of mammals can be passaged and expanded, resulting in differentiation into cell types of the central nervous system (CNS), including astrocytes, oligodendrocytes, and tyrosine-hydroxylase-positive neurons. Further disclosed are the means by which these precursor cells provide an accessible source for autologous transplantation in CNS, PNS, spinal cord and other damaged tissues. Therapeutic applications are provided, such as in the treatment of Parkinson's disease, Alzheimer's disease, Huntington's disease, Multiple Sclerosis, stroke and spinal cord injury.
Abstract:Current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. This invention relates to neural precursor cells (stem cells, progenitor cells or a combination of both types of cells) isolated from the olfactory epithelium of mammals that can be passaged and expanded, and that will differentiate into cell types of the central nervous system (CNS), including astrocytes, oligodendrocytes, and tyrosine-hydroxylase-positive neurons. These precursor cells provide an accessible source for autologous transplantation in CNS, PNS, spinal cord and other damaged tissues.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6969608
Application Number:US1997000920272
Date Filed:22/08/1997
Date Published:29/11/2005
Assignee:McGill University, Montreal, Canada


 
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