Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6982317

Title:C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity
Inventors:Basch, Ross S.; New York, NY, USA
Zhang, Xin-Min; Bronx, NY, USA
Summary:This invention describes a novel polypeptide that modulates the stability of transcriptional regulatory complexes in regulating nuclear hormone receptor activity. The invention relates to a gene in humans and mice, designated C21, which encodes a family of proteins that play a role in transcriptional regulation. Described herein are the two isoforms, alpha and beta, that have been identified in humans and which are produced by alternative splicing. Further described is a transgenic model that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Methods are included by which over-expression of C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. Claims of the invention include categorization of the C21 protein in a complex with a class of molecules that play a critical role in transcription as co-repressors of nuclear hormone receptors. Therapeutic applications in regulating stem cell differentiation and in modulating apoptosis are included.
Abstract:A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6982317
Application Number:US2001000987701
Date Filed:15/11/2001
Date Published:03/01/2006
Assignee:New York University, New York, NY, USA


 
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