|
|
|
Stem Cell Related Patent Number US6982317
| Title: | C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity | | Inventors: | Basch, Ross S.; New York, NY, USA
Zhang, Xin-Min; Bronx, NY, USA | | Summary: | This invention describes a novel polypeptide that modulates the stability of transcriptional regulatory complexes in regulating nuclear hormone receptor activity. The invention relates to a gene in humans and mice, designated C21, which encodes a family of proteins that play a role in transcriptional regulation. Described herein are the two isoforms, alpha and beta, that have been identified in humans and which are produced by alternative splicing. Further described is a transgenic model that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Methods are included by which over-expression of C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. Claims of the invention include categorization of the C21 protein in a complex with a class of molecules that play a critical role in transcription as co-repressors of nuclear hormone receptors. Therapeutic applications in regulating stem cell differentiation and in modulating apoptosis are included. | | Abstract: | A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6982317 | | Application Number: | US2001000987701 | | Date Filed: | 15/11/2001 | | Date Published: | 03/01/2006 | | Assignee: | New York University, New York, NY, USA |
|
|
