Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6991897

Title:Method of isolating stem cells
Inventors:Smith, Clayton A.; Tampa, FL, USA
Colvin, Michael; Chapel Hill, NC, USA
Storms, Robert W.; Durham, NC, USA
Ludeman, SUSA
n M.; Durham, NC, USA
Summary:This invention describes a method of detection and isolation of stem cells using a substrate for aldehyde dehydrogenase (ALDH) which is converted to a detectable product. The invention relates to contacting the population of cells with a detectable substrate for ALDH under conditions such that the ALDH present in the cells of the population converts the substrate to a detectable product which is then retained by the cells, such that the cells have a higher concentration of the detectable product than non-stem cells present in the population. The constituents of the substrate are disclosed, which include an aminoacetaldehyde component, as are therapeutic applications in organ transplantation and gene therapy.
Abstract:The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to stem cell populations isolatable in accordance with the present method.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6991897
Application Number:US2003000632377
Date Filed:01/08/2003
Date Published:31/01/2006
Assignee:Duke University, Durham, NC, USA


 
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