|
|
|
Stem Cell Related Patent Number US6994858
| Title: | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions | | Inventors: | Morris, Donald; Calgary, Canada
Thompson, Bradley G.; Calgary, Canada
Coffey, Matthew C.; Calgary, Canada | | Summary: | This invention describes methods of removing neoplastic cells from tissues and organs for transplant, using viruses that specifically target the neoplastic cells. It has been shown that reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. Herein the authors disclose particular methods for purging autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient. Precise techniques and compositions are provided. | | Abstract: | Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6994858 | | Application Number: | US2001000847356 | | Date Filed: | 03/05/2001 | | Date Published: | 07/02/2006 | | Assignee: | Oncolytics Biotech Inc., Calgary |
|
|
