Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6994858

Title:Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
Inventors:Morris, Donald; Calgary, Canada
Thompson, Bradley G.; Calgary, Canada
Coffey, Matthew C.; Calgary, Canada
Summary:This invention describes methods of removing neoplastic cells from tissues and organs for transplant, using viruses that specifically target the neoplastic cells. It has been shown that reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. Herein the authors disclose particular methods for purging autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient. Precise techniques and compositions are provided.
Abstract:Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6994858
Application Number:US2001000847356
Date Filed:03/05/2001
Date Published:07/02/2006
Assignee:Oncolytics Biotech Inc., Calgary


 
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