Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7022321

Title:Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
Inventors:Eglitis, Martin A.; Indianapolis, IN, USA
Mezey, Eva; Rockville, MD, USA
Mouradian, Mary Maral; Bethesda, MD, USA
Summary:Herein is described a method of introducing a growth factor gene or selective marker into the brain of a subject using bone marrow derived hematopoietic stem cells which have been transfected with a growth factor gene or a retroviral vector. The invention relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. Further described are methods by which the bone marrow-derived cell is preferably a cell that differentiates into a glial cell. Therapeutic applications are included.
Abstract:The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided. [From equivalent US20030003087A1] The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7022321
Application Number:US2002000122703
Date Filed:11/04/2002
Date Published:04/04/2006
Assignee:None


 
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