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Stem Cell Related Patent Number US7022321
| Title: | Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system | | Inventors: | Eglitis, Martin A.; Indianapolis, IN, USA
Mezey, Eva; Rockville, MD, USA
Mouradian, Mary Maral; Bethesda, MD, USA | | Summary: | Herein is described a method of introducing a growth factor gene or selective marker into the brain of a subject using bone marrow derived hematopoietic stem cells which have been transfected with a growth factor gene or a retroviral vector. The invention relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. Further described are methods by which the bone marrow-derived cell is preferably a cell that differentiates into a glial cell. Therapeutic applications are included. | | Abstract: | The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell.
The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein.
Isolated recombinant cells and a pharmaceutical composition are also provided.
[From equivalent US20030003087A1] The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell.
The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein.
Isolated recombinant cells and a pharmaceutical composition are also provided. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7022321 | | Application Number: | US2002000122703 | | Date Filed: | 11/04/2002 | | Date Published: | 04/04/2006 | | Assignee: | None |
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