Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7025981

Title:Therapeutic tool for vascular diseases
Inventors:Uchida, Yasumi; Funabashi-shi, Chiba, Japan
274-0063 Uchida, Haruko; Funabashi, Japan
Summary:This invention introduces a therapeutic tool that is coated with a dye-containing resin and is useful in the treatment of vascular disease. The dye-containing resin described herein comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye. Further described are therapeutic applications in the treatment of vascular conditions including percutaneous transluminal vasculoplasty, vascular bypass grafting, and for the prevention of vascular restenosis, through inhibition of the migration of vascular progenitor cells.
Abstract:The present invention relates to a therapeutic tool for vascular diseases, which is coated with a dye-containing resin that comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye; a medical treatment by the use of the therapeutic tool for vascular diseases; and a method of preventing vascular restenosis caused mainly through inhibition of migration of vascular progenitor cells by administering the medical treatment to a subject. Since the present therapeutic tool for vascular diseases is capable of staying in vivo for a long term, a medical treatment such as angioplasty (coronary angioplasty, peripheral angioplasty, cerebral angioplasty, etc.) and blood vessel bypass (coronary bypass, peripheral bypass) by the use of the present tool can effectively inhibit the generation of blood vessel restenosis by inhibiting migration of vascular progenitor cells. Thus, the present tool is extremely useful in clinical situations. [From equivalent US20030053952A1] The present invention relates to a therapeutic tool for vascular diseases, which is coated with a dye-containing resin that comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye; a medical treatment by the use of the therapeutic tool for vascular diseases; and a method of preventing vascular restenosis caused mainly through inhibition of migration of vascular progenitor cells by administering the medical treatment to a subject. Since the present therapeutic tool for vascular diseases is capable of staying in vivo for a long term, a medical treatment such as angioplasty (coronary angioplasty, peripheral angioplasty, cerebral angioplasty, etc.) and blood vessel bypass (coronary bypass, peripheral bypass) by the use of the present tool can effectively inhibit the generation of blood vessel restenosis by inhibiting migration of vascular progenitor cells. Thus, the present tool is extremely useful in clinical situations.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7025981
Application Number:US2002000237012
Date Filed:09/09/2002
Date Published:11/04/2006
Assignee:Uchida; Yasumi, Funabashi, Japan


 
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