Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7026284

Title:Formative agent of protein complex
Inventors:Gen, Shokyu; Kyoto, Japan
Summary:This invention describes a novel formative protein complex agent with a polyphenol component that is selected from a catechin group consisting of epigallocatechin-gallate, tannic acids, or proanto-dianisidine. Disclosed are methods by which the protein component of the complex is selected from animal proteins composed of a polypeptide chain of peptide-combined amino acids, vegetative proteins, nucleus proteins, glycogen proteins, lipo-proteins and metal proteins. Further described herein is a gene complex composed of genes containing polyphenol catechins, by which genes are introduced into the cells of animals or human bodies, via a cell adhesion inhibitor. Also described are animal cells such as stem, skin, mucosa, hepatocyte, islet, neural, cartilage, endothelial, epidermal, osteocyte and muscle cells that have been isolated from human or animal donor sperm, ovum or fertilized egg. Also provided are methods by which tissue and organ for transplantation of the immune tolerogen are selected. Therapeutic applications are included, for example as a gene complex, cell adhesion inhibitor or immune tolerogen in the treatment of arthritis, and as a sustained release preparation drug.
Abstract:The present invention proposes formative agent of protein complex, in which a polyphenol is useful component, and the agent is useful as gene complex, cell adhesion inhibitor or immune tolerogen. The polyphenol of forming the agent is selected from catechin group consisting of epigallocatechin-gallate, tannic acids, or proanto-dianisidine, a protein of the protein complex is selected from proteins consisting of animal proteins composed of polypeptide chain of peptide-combined amino acids, vegetative proteins, nucleus proteins, glycogen proteins, lipo-proteins and metal proteins, the gene complex comprises by compositing genes by polyphenol catechins in order to introduce genes to cells of animals or human bodies, a cell composed of the cell adhesion inhibitor is selected from cells consisting of an animal cell including a stem cell, skin cell, mucosa cell, hepatocyte, islet cell, neural cell, cartilage cell, endothelial cell, epidermal cell, osteocyte or muscle cell isolated from human or animal organism, or sperm, ovum or fertilized egg of domestic animals or fishes and a tissue or an organ for transplantation of the immune tolerogen is selected from the tissue or the organ consisting of skin, blood vessel, cornea, kidney, heart, liver, umbilical cord, bowels, nerve, lung, placenta or pancreas.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7026284
Application Number:US2002000085555
Date Filed:27/02/2002
Date Published:11/04/2006
Assignee:BMG Incorporated, Kyoto, Japan


 
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