Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7029666

Title:Uses for non-autologous mesenchymal stem cells
Inventors:Bruder, Scott P.; Waltham, MA, USA
McIntosh, Kevin R.; Ellicott City, MD, USA
Marshak, Daniel R.; Lutherville, MD, USA
Mosca, Joseph D.; Ellicott City, MD, USA
Summary:This invention describes methods and devices employing non-autologous mesenchymal stem cells for the treatment of a recipient. Further disclosed are methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment, and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest, particularly for the expression of physiologically or pharmacologically active proteins. Also included are therapeutic applications in gene therapy for the correction of genetic disorders or the rebuilding and repair of tissue, such as the use of non-autologous mesenchymal stem cells for the promotion of muscle tissue growth and connective tissue implantation, and the use of hematopoietic and progenitor cells in engraftment.
Abstract:Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment in an individual; and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins in gene therapy for correction of genetic disorders or “rebuilding” proteins important in tissue repair.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7029666
Application Number:US2002000046530
Date Filed:14/01/2002
Date Published:18/04/2006
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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