Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7030292

Title:Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
Inventors:Yan, Wen Liang; Potomac, MD, USA
Huang, Steve Chien-Wen; Germantown, MD, USA
Nguyen, Minh-Thanh; Rockville, MD, USA
Lin, Huan (Helen); N. Potomac, MD, USA
Lei, Jingqi; Gaithersburg, MD, USA
Khanna, Ruchi; Germantown, MD, USA
Summary:This invention describes a method of producing homozygous stem (HS) cells having a preselected target genotype and/or immunotype from non-fertilized post-meiosis I diploid germ cells. The invention relates to methods for using such histocompatible HS stem cells for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. Further described herein are methods of cataloging a transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnostic, therapeutic and transplantation applications.
Abstract:A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and/or transplantation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7030292
Application Number:US2002000032495
Date Filed:02/01/2002
Date Published:18/04/2006
Assignee:Stemron, Inc., Myersville, MD, USA


 
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