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Stem Cell Related Patent Number US7033794
| Title: | Basolateral sorting signal and inhibitors thereof | | Inventors: | Wehrle-Haller, Bernhard M.; Veyrier, Switzerland
Imhof, Beat A.; Conches, Switzerland | | Summary: | This invention describes a monoleucine-dependent, basolateral sorting signal useful for the modulation of the basolateral expression of basolaterally targeted transmembrane proteins. Specifically disclosed are the properties of a mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X1h2X3h4. Specific amino acid sequences are provided for such peptides or proteins comprising a basolateral sorting signal, along with the therapeutic uses thereof, such as applications in the treatment of cancer, atherosclerosis and psoriasis. | | Abstract: | Mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X1h2X3h4Lp5p6, wherein: X1 represents a polar amino acid residue or alanine, h2 represents any hydrophobic amino acid residue, X3 represents any amino a residue, h4 represents any hydrophobic amino acid residue, except leucine and isoleucine L represents a leucine residue, p5 represents any polar amino acid residue, and p6 represents any polar amino acid. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7033794 | | Application Number: | US2002000176791 | | Date Filed: | 20/06/2002 | | Date Published: | 25/04/2006 | | Assignee: | Universite de Geneve, Geneva, Switzerland |
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