Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7033794

Title:Basolateral sorting signal and inhibitors thereof
Inventors:Wehrle-Haller, Bernhard M.; Veyrier, Switzerland
Imhof, Beat A.; Conches, Switzerland
Summary:This invention describes a monoleucine-dependent, basolateral sorting signal useful for the modulation of the basolateral expression of basolaterally targeted transmembrane proteins. Specifically disclosed are the properties of a mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X1h2X3h4. Specific amino acid sequences are provided for such peptides or proteins comprising a basolateral sorting signal, along with the therapeutic uses thereof, such as applications in the treatment of cancer, atherosclerosis and psoriasis.
Abstract:Mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X1h2X3h4Lp5p6, wherein: X1 represents a polar amino acid residue or alanine, h2 represents any hydrophobic amino acid residue, X3 represents any amino a residue, h4 represents any hydrophobic amino acid residue, except leucine and isoleucine L represents a leucine residue, p5 represents any polar amino acid residue, and p6 represents any polar amino acid.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7033794
Application Number:US2002000176791
Date Filed:20/06/2002
Date Published:25/04/2006
Assignee:Universite de Geneve, Geneva, Switzerland


 
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