Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7033995

Title:Production of radial glial cells
Inventors:Weiss, Samuel; Calgary, Canada
Gregg, Christopher; Calgary, Canada
Summary:Described herein is a method of producing radial glial cells from neural stem cells or ependymal cells, via contacting the neural stem cells or ependymal cells with a radial glia-promoting agent. Methods for the use of epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2) and/or TGFalpha are also described, as is the optional addition of leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). The invention relates to the extraction of neural stem cells from the brain of a postnatal mammal, from which the radial glial cells may be generated. Therapeutic applications in the treatment or amelioration of central nervous system diseases are included.
Abstract:The present invention relates to a method of producing radial glial cells from neural stem cells, particularly by contacting neural stem cells with epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2) and/or TGFα. Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) can optionally be added to enhance the effect of EGF, FGF-1 or TGFα. Also provided are methods of producing radial glial cells from ependymal cells, as well as methods of proliferating ependymal cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7033995
Application Number:US2002000196549
Date Filed:17/07/2002
Date Published:25/04/2006
Assignee:Stem Cell Therapeutics Inc., Calgary, Canada


 
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