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Stem Cell Related Patent Number US7033995
| Title: | Production of radial glial cells | | Inventors: | Weiss, Samuel; Calgary, Canada
Gregg, Christopher; Calgary, Canada | | Summary: | Described herein is a method of producing radial glial cells from neural stem cells or ependymal cells, via contacting the neural stem cells or ependymal cells with a radial glia-promoting agent. Methods for the use of epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2) and/or TGFalpha are also described, as is the optional addition of leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). The invention relates to the extraction of neural stem cells from the brain of a postnatal mammal, from which the radial glial cells may be generated. Therapeutic applications in the treatment or amelioration of central nervous system diseases are included. | | Abstract: | The present invention relates to a method of producing radial glial cells from neural stem cells, particularly by contacting neural stem cells with epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2) and/or TGFα. Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) can optionally be added to enhance the effect of EGF, FGF-1 or TGFα. Also provided are methods of producing radial glial cells from ependymal cells, as well as methods of proliferating ependymal cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7033995 | | Application Number: | US2002000196549 | | Date Filed: | 17/07/2002 | | Date Published: | 25/04/2006 | | Assignee: | Stem Cell Therapeutics Inc., Calgary, Canada |
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