|
|
|
Stem Cell Related Patent Number US7037493
| Title: | Method of inducing neuronal production in the brain and spinal cord | | Inventors: | Goldman, Steven A.; South Salem, NY, USA
Benraiss, Abdellatif; Astoria, NY, USA | | Summary: | This invention describes a method of inducing medium spiny neurons in the post-natal and adult brain and spinal cord. Methods are described for the creation of a nucleic acid construct which encodes a brain-derived neurotrophic factor, and a nucleic acid construct which encodes noggin, both of which are in viral vectors. Methods are described for the injection of these viral vectors into a subject's lateral ventricles to infect the ventricular wall under conditions conducive to the expression of the neurotrophic factor and noggin, thereby inducing the addition of medium spiny neurons in any one or all of the caudate nucleus and the putamen of the subject. | | Abstract: | The present invention relates to methods of inducing neuronal production in the brain, recruiting neurons to the brain, and treating a neurodegenerative condition by providing a nucleic acid construct encoding a neurotrophic factor, and injecting the nucleic acid construct intraventricularly into a subject's brain. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7037493 | | Application Number: | US2001000846588 | | Date Filed: | 01/05/2001 | | Date Published: | 02/05/2006 | | Assignee: | Cornell Research Foundation, Inc., Ithaca, NY, USA |
|
|
