Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7037720

Title:Neuroepithelial stem cells and glial-restricted intermediate precursors
Inventors:Rao, Mahendra S.; Salt Lake City, UT, USA
Summary:Described herein are mammalian neuroepithelial stem cells and glial restricted precursor cells which can self renew and differentiate into central nervous system cells. Further described are multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells, of which the neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are also capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Also described are methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells. Therapeutic applications requiring the generation of various types of cells and tissue are included.
Abstract:Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7037720
Application Number:US2001000025333
Date Filed:19/12/2001
Date Published:02/05/2006
Assignee:University of Utah Research Foundation, Salt Lake City, UT, USA


 
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