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Stem Cell Related Patent Number US7037720
| Title: | Neuroepithelial stem cells and glial-restricted intermediate precursors | | Inventors: | Rao, Mahendra S.; Salt Lake City, UT, USA | | Summary: | Described herein are mammalian neuroepithelial stem cells and glial restricted precursor cells which can self renew and differentiate into central nervous system cells. Further described are multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells, of which the neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are also capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Also described are methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells. Therapeutic applications requiring the generation of various types of cells and tissue are included. | | Abstract: | Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7037720 | | Application Number: | US2001000025333 | | Date Filed: | 19/12/2001 | | Date Published: | 02/05/2006 | | Assignee: | University of Utah Research Foundation, Salt Lake City, UT, USA |
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