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Stem Cell Related Patent Number US7037892

Title:Hematopoietic stem cell proliferating agents
Inventors:Saito, Yoshimasa; Kawanishi, Japan
Ueda, Yoshiko; Osaka, Japan
Tamura, Kouichi; Kobe, Japan
Takata, Yoko; Osaka, Japan
Yamada, Hisashi; Sanda, Japan
Yamashita, Tatsuo; Kobe, Japan
Kobayashi, Masakazu; Takarazuka, Japan
Summary:Described herein is a hematopoietic stem cell proliferation agent containing IGF-I, and its uses in the culturing of hematopoietic stem cells. The invention relates to a method of culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. Further disclosed are methods of proliferating the hematopoietic stem cells in a mammal and administering IGF-I with at least one protein selected from the group consisting of M-CSF and G-CSF to the mammal, in an amount sufficient to stimulate hematopoietic stem cell proliferation.
Abstract:This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy. [From equivalent US20030068820A1] This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7037892
Application Number:US2002000198355
Date Filed:19/07/2002
Date Published:02/05/2006
Assignee:Astellas Pharma Inc., Tokyo, Japan


 
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