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Stem Cell Related Patent Number US7037900
| Title: | Composition and method for treating graft-versus-host disease | | Inventors: | DiMartino, Jorge; San Carlos, CA, USA
Nelson, John Tippett; Danville, CA, USA | | Summary: | This invention describes compositions and methods for the prevention and clinical treatment of various forms of graft-versus-host disease (GVHD). Such methods primarily employ inhibitors of adenosine deaminase (ADA). Various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug. This method therefore reduces the risk of developing graft-versus-host disease in a human patient who is a recipient of an organ or tissue transplant. | | Abstract: | Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7037900 | | Application Number: | US2001000976468 | | Date Filed: | 12/10/2001 | | Date Published: | 02/05/2006 | | Assignee: | SuperGen, Inc., Dublin, CA, USA |
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