Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7037900

Title:Composition and method for treating graft-versus-host disease
Inventors:DiMartino, Jorge; San Carlos, CA, USA
Nelson, John Tippett; Danville, CA, USA
Summary:This invention describes compositions and methods for the prevention and clinical treatment of various forms of graft-versus-host disease (GVHD). Such methods primarily employ inhibitors of adenosine deaminase (ADA). Various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug. This method therefore reduces the risk of developing graft-versus-host disease in a human patient who is a recipient of an organ or tissue transplant.
Abstract:Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7037900
Application Number:US2001000976468
Date Filed:12/10/2001
Date Published:02/05/2006
Assignee:SuperGen, Inc., Dublin, CA, USA


 
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