Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7037936

Title:Compounds useful for the treatment of cancer, compositions thereof and methods therewith
Inventors:McKenna, Jeffrey; San Diego, CA, USA
Mercurio, Frank; San Diego, CA, USA
Plantevin, Veronique; San Diego, CA, USA
Xie, Weilin; San Diego, CA, USA
Pagano, Michele; New York, NY, USA
Summary:Described herein are derivatives of tetrahydropyran or cyclohexane, their methods and uses. The invention relates to compounds and compositions useful for the modulation of ligase activity, specifically to inhibit or activate E3 ubiquitin-protein ligase. Further disclosed are methods of use as a preservative of cell, blood, tissue or organs or as an agent to modulate stem cells. Therapeutic applications are provided in the treatment and prevention of neoplastic disorders, acute or chronic renal failure, inflammatory disorders, immune disorders, cardiovascular disease, and various types of cancer.
Abstract:The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The invention further relates to the use of a Compound of the Invention as a preservative of a cell, blood, tissue or an organ or as an agent to modulate stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7037936
Application Number:US2003000463009
Date Filed:16/06/2003
Date Published:02/05/2006
Assignee:Signal Pharmaceuticals, LLC., San Diego, CA, USA


 
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