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| Title: | Antibodies to monocyte-colony inhibitory factor (M-CIF) |
| Inventors: | Gentz, Reiner L.; Belo Horizonte-Mg, Brazil
Kreider, Brent L.; Bedford, MA, USA Zhang, Jun; San Diego, CA, USA Antonaccio, Michael; New Hope, PA, USA Mendrick, Donna; Mount Airy, MD, USA Jimenez, Pablo; Chatham, NJ, USA Patel, Vikram; Germantown, MD, USA Rosen, Craig A.; Laytonsville, MD, USA Adams, Mark D.; Rockville, MD, USA Li, Haodong; Gaithersburg, MD, USA Ruben, Steven M.; Brookeville, MD, USA |
| Summary: | Described herein is a method for inhibiting the proliferation or differentiation of myeloid progenitor cells via the use of a myeloid progenitor inhibitory factor-1 amino-terminal deletion mutant. Further disclosed are therapeutic compositions and methods using the isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide. Specific amino acid sequences and residues are provided to which the isolated antibody or fragment thereof binds, along with therapeutic uses thereof. |
| Abstract: | There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US7041460 |
| Application Number: | US2003000626530 |
| Date Filed: | 25/07/2003 |
| Date Published: | 09/05/2006 |
| Assignee: | Human Genome Sciences, Inc., Rockville, MD, USA |