Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7041460

Title:Antibodies to monocyte-colony inhibitory factor (M-CIF)
Inventors:Gentz, Reiner L.; Belo Horizonte-Mg, Brazil Kreider, Brent L.; Bedford, MA, USA
Zhang, Jun; San Diego, CA, USA
Antonaccio, Michael; New Hope, PA, USA
Mendrick, Donna; Mount Airy, MD, USA
Jimenez, Pablo; Chatham, NJ, USA
Patel, Vikram; Germantown, MD, USA
Rosen, Craig A.; Laytonsville, MD, USA
Adams, Mark D.; Rockville, MD, USA
Li, Haodong; Gaithersburg, MD, USA
Ruben, Steven M.; Brookeville, MD, USA
Summary:Described herein is a method for inhibiting the proliferation or differentiation of myeloid progenitor cells via the use of a myeloid progenitor inhibitory factor-1 amino-terminal deletion mutant. Further disclosed are therapeutic compositions and methods using the isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide. Specific amino acid sequences and residues are provided to which the isolated antibody or fragment thereof binds, along with therapeutic uses thereof.
Abstract:There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7041460
Application Number:US2003000626530
Date Filed:25/07/2003
Date Published:09/05/2006
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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