Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7056738

Title:Early stage multipotential stem cells in colonies of bone marrow stromal cells
Inventors:Prockop, Darwin J.; New Orleans, LA, USA
Colter, David C.; Philadelphia, PA, USA
Sekiya, Ichiro; New Orleans, LA, USA
Summary:This invention describes a population of cells comprising two classes of bone marrow stem cells (MSCs), one of which are small and rapidly self-renewing stem (RS) cells, and the other of which are large, more mature marrow stromal cells (mMSCs). Described herein are adult bone marrow stromal cells (MSCs) that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs have been shown to contain both the small, rapidly self-renewing stem cells (RS cells) and the large, more mature cells (mMSCs), enriched samples of which exhibited a greater potential for multipotent differentiation from the RS cells than from the mMSCs. The RS cells were also shown to have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. Results are described suggesting important distinguishing features between the two major sub-populations of MSCs in defining their biological and clinical potentials for cell and gene therapy.
Abstract:Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS cells had a greater potential for multipotential differentiation than samples enriched for mMSCs. Also, RS cells have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. The results suggest that it will be important to distinguish the two major sub-populations of MSCs in defining their biology and their potentials for cell and gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7056738
Application Number:US2001000816182
Date Filed:23/03/2001
Date Published:06/06/2006
Assignee:Tulane University, New Orleans, LA, USA Philadelphia Heath and Education Corporation, Philadelphia, PA, USA


 
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