Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7071373

Title:Transgenic ungulate compositions and methods
Inventors:Wheeler, Matthew B.; Tolono, IL, USA
Summary:Described herein is a transgenic chimeric ungulate, and methods and uses thereof. This invention relates to processes by which a cultured ungulate embryonic stem cell line yields a chimeric ungulate embryo, and the environmental conditions in which such a chimeric ungulate embryo is allowed to develop. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines, and methods for establishing such cell lines. Also described are methods of transforming the lines with exogenous genetic material which is then used to provide chimeric ungulates confirmed by genetic markers which have germ cells comprising the exogenous genetic material. Methods are further described by which the chimeric ungulates are bred to provide transgenic ungulates. The authors describe means by which the transgenic animals may show improved qualities, and may be used to provide human proteins or peptide hormones, or as xenograft donors.
Abstract:Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates confirmed by genetic markers which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7071373
Application Number:US1995000410539
Date Filed:24/03/1995
Date Published:04/07/2006
Assignee:The Board of Trustees of the University of Illinois, Urbana, IL, USA


 
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