Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7078230

Title:Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell
Inventors:Wilkison, William O.; Bahama, NC, USA
Gimble, Jeffrey; Chapel Hill, NC, USA
Summary:This invention describes an adipose tissue-derived stromal cell that is capable of being induced to express phenotypic characteristics of neuronal, astroglial, hematopoietic progenitor or hepatic cells. Described herein are such pleuripotent stem cells and their expressed neuronal markers, which are selected from the group consisting of neuron-specific protein (NeuN), neurofilament medium polypeptide (NF-M), neuron-specific enolase (NSE), nestin, trkA, class III beta-tubulin, M subunit of neurofilaments, tyrosine hydroxylase, glutamate receptor subunits of the GluR14 and GluR6 classes, glial fibrillary acidic protein, myelin basic protein, and brain factor 1. Also disclosed is an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers. Applications in autologous and allogenic transplantations are included.
Abstract:The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. The invention also includes an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7078230
Application Number:US2001000793173
Date Filed:26/02/2001
Date Published:18/07/2006
Assignee:Artecel, Inc., Baltimore, MD, USA


 
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