Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7078231

Title:Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
Inventors:Roberts, Penelope E; Millbrae, CA, USA
Mather, Jennie Powell; Millbrae, CA, USA
Summary:Described herein is a population of human pancreatic progenitor cells which can differentiate into functional exocrine or endocrine cells. The invention relates to a substantially pure population of human pancreatic progenitor cells and methods of isolating and culturing the pancreatic progenitor cells by careful manipulation of the microenvironment. Methods are described by which multiple passages are attainable such that the pancreatic progenitor cells do not senesce and are capable of becoming functional exocrine or endocrine cells. Also included are applications as immunogens in cell and gene therapy, and as a way of providing cell therapy to a human recipient lacking or having functionally defective pancreatic epithelial cells.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US7078231
Application Number:US2002000119601
Date Filed:09/04/2002
Date Published:18/07/2006
Assignee:Raven biothechnologies, inc., South San Francisco, CA, USA


 
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