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| Title: | Monkey-origin embryonic stem cells |
| Inventors: | Nakatsuji, Norio; Kyoto, Japan Tada, Takashi; Kyoto, Japan Torii, Ryuzo; Moriyama, Japan Hosoi, Yoshihiko; Sakai, Japan Iritani, Akira; Kyoto, Japan Akuta, Teruo; Kumamoto, Japan |
| Summary: | This invention describes embryonic stem cells originating in Macaca fascicularis, and uses thereof. Described herein is a method for producing a monkey-derived embryonic stem cell line via fertilization by insemination, in vitro fertilization or intracytoplasmic sperm injection using monkey-derived ova and sperm. After the fertilized ovum has differentiated into a blastocyst by in vitro culture and an ES cell line has been established, methods are described for screening a reagent for the specific differentiation into specific cells or tissue. Various clinical and experimental applications in genetics are described. |
| Abstract: | A method for producing a monkey-derived embryonic stem cell comprising the steps of carrying out fertilization by insemination by in vitro fertilization or intracytoplasmic sperm injection using a monkey ovum and monkey sperms, thereby giving a fertilized ovum, allowing the fertilized ovum to differentiate into a blastocyst by in vitro culture, and establishing an ES cell line using the blastocyst; the monkey ES cell obtained by the method, a method for screening a reagent for specific differentiation into cell or tissue by using the ES cell; and a differentiated cell or differentiated tissue each differentiated from the ES cell. According to the present invention, applications of the embryonic stem cells to embryological studies clinical applications, experimental models, and the like on primates, studies of diseases, are expected. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US7083977 |
| Application Number: | US2001000311146 |
| Date Filed: | 15/06/2001 |
| Date Published: | 01/08/2006 |
| Assignee: | Tanabe Seiyaku Co., Ltd., Osaka, Japan |