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| Title: | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
| Inventors: | Lieber, André; Seattle, WA, USA Shayakhmetov, Dmitry M; Seattle, WA, USA Farrer, Denise R; Seattle, WA, USA Papayannopoulou, Thalia; Seattle, WA, USA Stamatoyannopoulos, George; Seatte, WA, USA |
| Summary: | This invention describes a recombinant adenoviral vector containing a transgene, and its uses in producing gutless vectors for gene therapy which are targetable to selected cells and are lacking antigenicity. Further disclosed are novel chimeric Ad-vectors carrying the transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or alphaupsilonbeta3/5-independent manner. Also provided are methods for producing such vectors and their use in gene therapy to target a specific cell type or tissue. Fully detailed is a recombinant, double-stranded, adenovirus vector and its properties, as well as the potential therapeutic uses thereof. |
| Abstract: | The present invention provides for novel chimeric Ad-vectors carrying transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or αυβ3/5-independent manner. Also provided are methods for producing such vectors and the use thereof for gene therapy to target a specific cell type or tissue. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US7094398 |
| Application Number: | US2000000980564 |
| Date Filed: | 01/06/2000 |
| Date Published: | 22/08/2006 |
| Assignee: | University of Washington, Seattle, WA, USA |