Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7094398

Title:Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
Inventors:Lieber, André; Seattle, WA, USA
Shayakhmetov, Dmitry M; Seattle, WA, USA
Farrer, Denise R; Seattle, WA, USA
Papayannopoulou, Thalia; Seattle, WA, USA
Stamatoyannopoulos, George; Seatte, WA, USA
Summary:This invention describes a recombinant adenoviral vector containing a transgene, and its uses in producing gutless vectors for gene therapy which are targetable to selected cells and are lacking antigenicity. Further disclosed are novel chimeric Ad-vectors carrying the transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or alphaupsilonbeta3/5-independent manner. Also provided are methods for producing such vectors and their use in gene therapy to target a specific cell type or tissue. Fully detailed is a recombinant, double-stranded, adenovirus vector and its properties, as well as the potential therapeutic uses thereof.
Abstract:The present invention provides for novel chimeric Ad-vectors carrying transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or αυβ3/5-independent manner. Also provided are methods for producing such vectors and the use thereof for gene therapy to target a specific cell type or tissue.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7094398
Application Number:US2000000980564
Date Filed:01/06/2000
Date Published:22/08/2006
Assignee:University of Washington, Seattle, WA, USA


 
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