Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
 |
|
|
||||||||||||||||||||||||||||||||||||||||||
| Title: | High dose radionuclide complexes for bone marrow suppression |
| Inventors: | Fritzberg, Alan R.; Olga, WA, USA Abrams, Paul G.; Seattle, WA, USA Tatalick, Lauren Marie; Redmond, WA, USA Thoelke, Kent R.; Seattle, WA, USA Bryan, James Kyle; Seattle, WA, USA Hylarides, Mark D.; Stanwood, WA, USA John, Elizabeth K.; San Diego, CA, USA |
| Summary: | This invention describes a method for the treatment of osteomyelitis, in which a composition comprising a ligand-complexed radionuclide is administered to a subject suffering from osteomyelitis. Methods are also disclosed for the suppression of bone marrow in the treatment of cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid. Methods are also described for the augmentation of the subject’s bone marrow following such treatment, via transplantation with purged autologous or matched allogeneic bone marrow, including peripheral blood stem cells, and/or by treatment with bone marrow-stimulating agents. |
| Abstract: | The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US7097823 |
| Application Number: | US2004000784476 |
| Date Filed: | 23/02/2004 |
| Date Published: | 29/08/2006 |
| Assignee: | NeoRx Corporation, Seattle, WA, USA |