|
|
|
Stem Cell Related Patent Number US7101708
| Title: | Hematopoietic cell composition for use in transplantation | | Inventors: | Lapidot, Tsvee; Nes-Ziona, Israel
Peled, Amnon; Tel-Aviv, Israel | | Summary: | This invention describes a novel composition comprised of a mammalian hematopoietic stem and progenitor cell expressing the chemokine receptor CXCR4+, and uses thereof. The composition described herein consists essentially of mammalian hematopoietic CD38?-/low CXCR4+ stem and progenitor cells and has been shown to exhibit a migrating response to stromal-derived factor 1 (SDF-1). Properties by which it is capable of adhering to stromal cells in response to an adhesion-inducing agent are further described. Methods are provided by which hematopoietic CXCR4-/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. Therapeutic applications in clinical transplantation are included. | | Abstract: | Cell compositions consisting essentially of mammalian hematopoietic CXCR4+ stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4−/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. The composition consists preferably of human CD38−/low CXCR44 cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7101708 | | Application Number: | US1999000744654 | | Date Filed: | 20/07/1999 | | Date Published: | 05/09/2006 | | Assignee: | Yeda Research and Development Co. Ltd., Rehovot, Israel |
|
|
