Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7101708

Title:Hematopoietic cell composition for use in transplantation
Inventors:Lapidot, Tsvee; Nes-Ziona, Israel Peled, Amnon; Tel-Aviv, Israel
Summary:This invention describes a novel composition comprised of a mammalian hematopoietic stem and progenitor cell expressing the chemokine receptor CXCR4+, and uses thereof. The composition described herein consists essentially of mammalian hematopoietic CD38?-/low CXCR4+ stem and progenitor cells and has been shown to exhibit a migrating response to stromal-derived factor 1 (SDF-1). Properties by which it is capable of adhering to stromal cells in response to an adhesion-inducing agent are further described. Methods are provided by which hematopoietic CXCR4-/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. Therapeutic applications in clinical transplantation are included.
Abstract:Cell compositions consisting essentially of mammalian hematopoietic CXCR4+ stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4−/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. The composition consists preferably of human CD38−/low CXCR44 cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7101708
Application Number:US1999000744654
Date Filed:20/07/1999
Date Published:05/09/2006
Assignee:Yeda Research and Development Co. Ltd., Rehovot, Israel


 
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