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Stem Cell Related Patent Number US7105150
| Title: | In vivo screening methods using enriched neural stem cells | | Inventors: | Buck, David W.; Heathfield, United Kingdom
Uchida, Nobuko; Palo Alto, CA, USA
Weissman, Irving; Redwood City, CA, USA | | Summary: | Described herein are methods of isolation, enrichment and selection of neural cells and neurosphere-initiating cells (NS-IC). Also disclosed are enriched neural stem and progenitor cell populations, and methods for the identification, isolation and enrichment of such cells using a reagent that bind to cell surface markers. The invention relates to a method of drug screening which incorporates selecting from a population of neural or neural-derived cells those cells which bind to the monoclonal antibodies AC133 or 5E12, thereby producing a population enriched for human NS-IC. Also provided are methods of engrafting, administration and comparison. Applications in the treatment of central nervous system disorders are included. | | Abstract: | Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7105150 | | Application Number: | US2001000792098 | | Date Filed: | 23/02/2001 | | Date Published: | 12/09/2006 | | Assignee: | StemCells California, Inc., Palo Alto, CA, USA |
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