Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7105150

Title:In vivo screening methods using enriched neural stem cells
Inventors:Buck, David W.; Heathfield, United Kingdom
Uchida, Nobuko; Palo Alto, CA, USA
Weissman, Irving; Redwood City, CA, USA
Summary:Described herein are methods of isolation, enrichment and selection of neural cells and neurosphere-initiating cells (NS-IC). Also disclosed are enriched neural stem and progenitor cell populations, and methods for the identification, isolation and enrichment of such cells using a reagent that bind to cell surface markers. The invention relates to a method of drug screening which incorporates selecting from a population of neural or neural-derived cells those cells which bind to the monoclonal antibodies AC133 or 5E12, thereby producing a population enriched for human NS-IC. Also provided are methods of engrafting, administration and comparison. Applications in the treatment of central nervous system disorders are included.
Abstract:Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7105150
Application Number:US2001000792098
Date Filed:23/02/2001
Date Published:12/09/2006
Assignee:StemCells California, Inc., Palo Alto, CA, USA


 
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