|
|
|
Stem Cell Related Patent Number US7112409
| Title: | Method of determining cytokine dosage for myelosuppressive state | | Inventors: | Blumenthal, Rosalyn D.; Belleville, NJ, USA
Goldenberg, David M.; Mendham, NJ, USA | | Summary: | This invention describes a method of adjusting the dose of a myelosuppressive agent to be administered to a patient, involving the measurement of the level of one or more hematopoietic cytokines in a sample from the patient, and the comparison of that level of the hematopoietic cytokine to a normal level. Such kits and procedures for evaluating the myelosuppressive state of a patient provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity while simultaneously maximizing dose effectiveness. Precise hematopoietic cytokine and stem cell factor properties are further disclosed. | | Abstract: | The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7112409 | | Application Number: | US2002000173550 | | Date Filed: | 14/06/2002 | | Date Published: | 26/09/2006 | | Assignee: | Center for Molecular Medicine and Immunology, Belleville, NJ, USA |
|
|
