Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7115360

Title:Isolation and use of solid tumor stem cells
Inventors:Clarke, Michael F.; Ann Arbor, MI, USA
Morrison, Sean J.; Ann Arbor, MI, USA
Wicha, Max S.; Ann Arbor, MI, USA
al-Hajj, Muhammad; La Jolla, CA, USA
Summary:Described herein is a method for the isolation of solid tumor stem cells expressing the cell surface marker CD44. It has been shown that a small percentage of cells within an established solid tumor have the properties of stem cells, such that these solid tumor stem cells give rise both to more tumor stem cells and to the majority of the cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. This invention therefore relates to principles by which solid tumor heterogeneity has been found to reflect the presence of tumor cell progeny arising from a solid tumor stem cell. Further disclosed herein are methods for determining the ability of compounds to inhibit tumorigenesis in solid tumor stem cells of epithelial origin. Therapeutic applications are included for the identification of new anti-cancer drug targets, and for factors influencing tumor stem cell proliferation.
Abstract:A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7115360
Application Number:US2001000343692
Date Filed:02/08/2001
Date Published:03/10/2006
Assignee:Regents of the University of Michigan, Ann Arbor, MI, USA


 
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