Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7115417

Title:Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
Inventors:Chancellor, Michael B.; Pittsburg, PA, USA
Huard, Johnny; Pittsburgh, PA, USA
Capelli, Christopher C.; Kenosha, WI, USA
Qu, Zhuqing; Pittsburgh, PA, USA
Summary:Described herein is the use of a composition comprising isolated muscle-derived progenitor cells (MDCs) expressing cell markers having long-term survivability in situ. This invention relates to muscle-derived progenitor cells that exhibit an ability to survive long-term following transplantation into body tissue, resulting in the augmentation of soft tissue. Also included are such methods of introduction, which include injection, transplantation, and implantation. Methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy are further described, as are methods of suspension, isolation and plating. The invention additionally provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, such as malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
Abstract:The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7115417
Application Number:US2000000549937
Date Filed:14/04/2000
Date Published:03/10/2006
Assignee:None


 
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